-
Product Name
Human UBE2M/UBC12 recombinant protein
- Documents
-
Description
UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
-
Protein name
ubiquitin conjugating enzyme E2 M(UBE2M)
-
Protein short names
UBC12
-
Uniprot ID
P61081
-
Source/Expression Host
E.coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the Human UBE2M/UBC12 Met1-Lys183 is expressed.
-
Protein Species
Human
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Human UBE2M/UBC12 recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"