Mouse VEGFR3/FLT-4 (His Tag) recombinant protein

Cat.#: 503672

Size:

Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Mouse VEGFR3/FLT-4 (His Tag) recombinant protein
  • Documents
  • Description
    Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.
  • Protein name
    Vascular endothelial growth factor receptor 3
  • Protein short names
    CHY; PCL; VEGFR-3; VEGFR3; RP23-58E13.1; AI323512; FLT41; LMPH1A; FLT4; FLT-4
  • Uniprot ID
    P35917
  • Gene Name
    Flt4; Flt-4; Vegfr3
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse FLT4 (P35917-1) extracellular domain (Met 1-Glu 775) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse FLT4 consists of 762 amino acids and has a predicted molecular mass of 86.4 kDa. The apparent molecular mass of rm FLT4 is approximately 95-105 kDa due to glycosylation in non-reduced SDS-PAGE.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized mouse VEGFR3-His (Cat:503672) at 10 μg/mL (100 μl/well) can bind mouse Fc-VEGFD, The EC50 of mouse Fc-VEGFD is 44 ng/mL.
  • Validations

    Mouse VEGFR3 / FLT-4 Protein (His Tag) SDS-PAGE

    Mouse VEGFR3 / FLT-4 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"