Mouse VEGFR3/FLT-4 (His Tag) recombinant protein

Mouse VEGFR3/FLT-4 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.

Vascular endothelial growth factor receptor 3

CHY; PCL; VEGFR-3; VEGFR3; RP23-58E13.1; AI323512; FLT41; LMPH1A; FLT4; FLT-4

P35917

Flt4; Flt-4; Vegfr3

Human Cells

A DNA sequence encoding the mouse FLT4 (P35917-1) extracellular domain (Met 1-Glu 775) was expressed, with a polyhistidine tag at the C-terminus.

Mouse

The secreted recombinant mouse FLT4 consists of 762 amino acids and has a predicted molecular mass of 86.4 kDa. The apparent molecular mass of rm FLT4 is approximately 95-105 kDa due to glycosylation in non-reduced SDS-PAGE.

> 97 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized mouse VEGFR3-His (Cat:503672) at 10 μg/mL (100 μl/well) can bind mouse Fc-VEGFD, The EC₅₀ of mouse Fc-VEGFD is 44 ng/mL.