-
Product Name
Mouse Tnfrsf10b/Dr5/Killer (Fc tag) recombinant protein
- Documents
-
Description
Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.
-
Protein name
tumor necrosis factor receptor superfamily, member 10b(Tnfrsf10b)
-
Protein short names
Dr5; Killer
-
Uniprot ID
Q9QZM4
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Tnfrsf10b/Dr5/Killer Asn53-Ser177 is expressed with a Fc tag at the C-terminus.
-
Protein Species
Mouse
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Mouse Tnfrsf10b/Dr5/Killer (Fc tag) recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"