Mouse IL17 / IL17a recombinant protein

Mouse IL17 / IL17a recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Interleukin-17A

INTERLEUKIN-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8. INTERLEUKIN-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED SERINE ESTERASE 8; IL-17; CTLA-8; IL-17A; IL17; INTERLEUKIN 17 (CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED SERINE ESTERASE 8); CTLA8; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 8; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8

Q62386

Il17a; Ctla8; Il17

E. coli

A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.

Mouse

The recombinant mouse IL17a consists of 138 amino acids and predicts a molecular mass of 15.5 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant mouse IL17a (Cat:503385) at 10 μg/mL (100 μl/well) can bind human IL17Ra-Fc2h (Cat:503306) with a linear range of 16-500 ng/mL.