NovoPro
Cart 2
  • Mouse Complement Factor H (His Tag) recombinant protein

Mouse Complement Factor H (His Tag) recombinant protein

Cat.#: 504127

Size:

Special Price 307.5 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Mouse Complement Factor H (His Tag) recombinant protein
  • Documents
  • Description
    Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.
  • Protein name
    Complement factor H
  • Protein short names
    SAS-1; SAS1; NOM; FHL1; HF1; ARMD4; AHUS1; MGC88246; COMPLEMENT FACTOR H; HUS; HF2; CFHL3; ARMS1; HF; AMBP1; CFH; FH; RP1-177P10.1; MUD-1
  • Uniprot ID
    P06909
  • Gene Name
    Cfh
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Cfh (NP_034018.2) (Ser875-Val1252) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Cfh consists 389 amino acids and predicts a molecular mass of 43.8 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Mouse Complement Factor H Protein (His Tag)

    Mouse Complement Factor H Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"