Human CFH/HF/HF1/HF2 (His tag) recombinant protein

Human CFH/HF/HF1/HF2 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses, because it binds to glycosaminoglycans (GAGs) that are generally present on host cells but not, normally, on pathogen surfaces.

complement factor H(CFH)

HF; HF1; HF2

P08603-2

Human Cells

A DNA sequence encoding the Human CFH/HF/HF1/HF2 Glu19-Leu449 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.