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Product Name
Human CD14 (Fc Tag) recombinant protein
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Description
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
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Protein name
Monocyte differentiation antigen CD14
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Protein short names
MONOCYTE DIFFERENTIATION ANTIGEN CD14; CD14 ANTIGEN; CD14
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Uniprot ID
P08571
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Gene Name
CD14
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Thr 20-Cys 352) of the mature form of human CD14 (NP_000582.1) was fused to the Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human Fc/CD14 chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 570 amino acids and has a calculated molecular mass of 62.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhFc/CD14 monomer is approximately 75-85 kDa due to the glycosylation.
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Purity
> 97 % as determined by SDS-PAGE and SEC-HPLC Analysis.
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Validations
Human CD14 Protein (Fc Tag) SDS-PAGE
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