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Product Name
Mouse CD14 (His & Fc Tag) recombinant protein
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Description
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).
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Protein name
Monocyte differentiation antigen CD14
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Protein short names
CD14; MONOCYTE DIFFERENTIATION ANTIGEN CD14; CD14 ANTIGEN
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Uniprot ID
Q4FJP7
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Gene Name
Cd14
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Pro 345) of mouse CD14 (NP_033971.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CD14/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 578 amino acids and has a predicted molecular mass of 63.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CD14/Fc monomer is approximately 85-95 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse CD14 Protein (His & Fc Tag) SDS-PAGE
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