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Rat LTBR/TNFRSF3 (Fc Tag) recombinant protein

Cat.#: 501086

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Product Information

  • Product Name
    Rat LTBR/TNFRSF3 (Fc Tag) recombinant protein
  • Documents
  • Description
    LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.
  • Protein name
    Lymphotoxin B receptor
  • Protein short names
    TUMOR NECROSIS FACTOR RECEPTOR 2-RELATED PROTEIN; TNFRSF3; AI256028; TUMOR NECROSIS FACTOR C RECEPTOR; TNFR3; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; TNFR-III; TNFR SUPERFAMILY; D12S370; TNFRRP; TNFR2-RP; TUMOR NECROSIS FACTOR RECEPTOR TYPE III; TNF-RIII; TNFR-RP; TNFBR; TNF-R-III; LT-BETA-R; TNF RECEPTOR-RELATED PROTEIN; CD18; LYMPHOTOXIN-BETA RECEPTOR; TNFCR; LTBETAR; LT-BETA RECEPTOR; LTAR; LT BETA-R; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY; MEMBER 3; LYMPHOTOXIN B RECEPTOR
  • Uniprot ID
    Q5U2S8
  • Gene Name
    Ltbr; rCG_29964
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat LTBR (Q5U2S8) (Met1-Ala218) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat LTBR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 432 amino acids and has a predicted molecular mass of 48.5 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
  • Purity
    (9.8+79.7) % as determined by SDS-PAGE
  • Validations

    Rat LTBR / TNFRSF3 Protein (Fc Tag) SDS-PAGE

    Rat LTBR / TNFRSF3 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"