Rat LTBR/TNFRSF3 (His Tag) recombinant protein

Rat LTBR/TNFRSF3 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.

Lymphotoxin B receptor

TNFR3; AI256028; TUMOR NECROSIS FACTOR C RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 2-RELATED PROTEIN; TNFRSF3; TNFR-III; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; TNFR2-RP; D12S370; TNFRRP; TNFR SUPERFAMILY; TNFR-RP; TNF-RIII; TUMOR NECROSIS FACTOR RECEPTOR TYPE III; TNF RECEPTOR-RELATED PROTEIN; LT-BETA-R; TNFBR; TNF-R-III; LYMPHOTOXIN-BETA RECEPTOR; CD18; LT BETA-R; LTAR; LTBETAR; LT-BETA RECEPTOR; TNFCR; LYMPHOTOXIN B RECEPTOR; MEMBER 3; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY

Q5U2S8

Ltbr; rCG_29964

Human Cells

A DNA sequence encoding the rat LTBR (NP_001008316.1) extracellular domain (Met 1-Ala 218) was expressed, fused with a polyhistidine tag at the C-terminus.

Rat

The recombinant rat LTBR comprises 202 amino acids and predicts a molecular mass of 23 kDa. The apparent molecular mass of the ratLTBR is approximately 35 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 96 % as determined by SDS-PAGE