Cynomolgus LTBR/TNFRSF3 (Fc Tag) recombinant protein

Cynomolgus LTBR/TNFRSF3 (Fc Tag) recombinant protein

• DataSheet
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LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.

Tumor necrosis factor receptor superfamily member 3

TNF RECEPTOR-RELATED PROTEIN; LT-BETA-R; TNFBR; TNF-R-III; LYMPHOTOXIN-BETA RECEPTOR; CD18; LT BETA-R; LTAR; LT-BETA RECEPTOR; LTBETAR; TNFCR; LYMPHOTOXIN B RECEPTOR; MEMBER 3; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY; TNFR3; AI256028; TUMOR NECROSIS FACTOR C RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 2-RELATED PROTEIN; TNFRSF3; TNFR-III; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; TNFR2-RP; D12S370; TNFRRP; TNFR SUPERFAMILY; TNFR-RP; TNF-RIII; TUMOR NECROSIS FACTOR RECEPTOR TYPE III

F6V995

LTBR

Human Cells

A DNA sequence encoding the cynomolgus LTBR (F6V995) (Met1-Met225) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus LTBR is a disulfide-linked homodimer. The reduced monomer comprises 439 amino acids and has a calculated molecular mass of 48.8 KDa. The apparent molecular mass of the protein is approximately 64-70 KDa respectively in SDS-PAGE.

> 85 % as determined by SDS-PAGE