Mouse Ly108/SLAMF6 (His Tag) recombinant protein

Mouse Ly108/SLAMF6 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Ly108s

LY108; MGC104953; SF2000; KALI; CD352; SLAMF6; FLJ50657; NTBA; KAL1B; KAL1; KALIB; RP11-528G1.1; NTB-A

Q9ET39

Slamf6; Ly108s; mCG_4493

Human Cells

A DNA sequence encoding the mouse SLAMF6 (NP_109635.1) extracellular domain (Met 1-Asn 239) was fused with a polyhistidine tag at the C-terminus.

Mouse

The recombinant mouse SLAMF6 consists of 220 amino acids and has a predicted molecular mass of 24.4 kD. The apparent molecular mass of the rmSLAMF6 protein is approximately 40-45 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.