Human SLAMF6/KALI/UNQ6123/PRO20080 (His tag) recombinant protein

Human SLAMF6/KALI/UNQ6123/PRO20080 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.

SLAM family member 6(SLAMF6)

KALI; UNQ6123; PRO20080

Q96DU3

Human Cells

A DNA sequence encoding the Human SLAMF6/KALI/UNQ6123/PRO20080 Leu28-Lys225 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.