Human Ly108/SLAMF6 (His Tag) recombinant protein

Human Ly108/SLAMF6 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

SLAM family member 6

NTBA; SLAMF6; FLJ50657; NTB-A; KALIB; KAL1; KAL1B; RP11-528G1.1; KALI; MGC104953; LY108; SF2000; CD352

Q96DU3

SLAMF6; KALI; UNQ6123/PRO20080

Human Cells

A DNA sequence encoding the human SLAMF6 (Q96DU3-1) extracellular domain (Met 1-Met 226) was expressed, with a polyhistidine tag at the C-terminus.

Human

The recombinant human SLAMF6 consists of 216 amino acids and predictes a molecular mass of 24.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSLAMF6 is approximately 38-40 kDa due to glycosylation.

> 90 % as determined by SDS-PAGE

Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.