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Product Name
Mouse Leukotriene A4 Hydrolase/LTA4H (His Tag) recombinant protein
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Description
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
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Protein name
Leukotriene A-4 hydrolase
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Protein short names
LTA4H; LTA4 HYDRODASE; LEUKOTRIENE A4 HYDROLASE
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Uniprot ID
P24527
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Gene Name
Lta4h
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse LTA4H (NP_032543.2) (Met 1-Asp 611) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse LTA4H consists of 621 amino acids and has a calculated molecular mass of 70.4 kDa. It migrates as an approximately 62 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (R-AMC). The specific activity is >15 pmoles/min/μg.
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Validations
Mouse Leukotriene A4 Hydrolase / LTA4H Protein (His Tag) SDS-PAGE
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