Anti-Leukotriene A4 Hydrolase/LTA4H antibody

Anti-Leukotriene A4 Hydrolase/LTA4H antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Leukotriene A4 Hydrolase/LTA4H

ELISA, WB, IP

Human Leukotriene A4 Hydrolase / LTA4H

Leukotriene A4 Hydrolase antibody; Leukotriene A4 Hydrolase antibody; LTA4 hydrodase antibody; Lta4h antibody; LTA4H antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human Leukotriene A4 Hydrolase / LTA4H (rh Leukotriene A4 Hydrolase / LTA4H; NP_000886.1; Met 1-Asp 611). Leukotriene A4 Hydrolase / LTA4H specific IgG was purified by Human Leukotriene A4 Hydrolase / LTA4H affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Mouse leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

• Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
• Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
• Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
• Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.