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Product Name
Human Leukotriene A4 Hydrolase/LTA4H (His Tag) recombinant protein
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Description
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
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Protein name
Leukotriene A-4 hydrolase
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Protein short names
LTA4 HYDRODASE; LTA4H; LEUKOTRIENE A4 HYDROLASE
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Uniprot ID
P09960
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Gene Name
LTA4H; LTA4
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human LTA4H (NP_000886.1) (Met1-Asp611) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The recombinant human LTA4H consists of 621 amino acids and predicts a molecular mass of 70.7 kDa. It migrates as approximately 58-68 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin(R-AMC).
The specific activity is > 15 pmoles/min/μg. -
Validations
Human Leukotriene A4 Hydrolase / LTA4H Protein (His Tag) SDS-PAGE
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