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Product Name
Mouse IL-21 recombinant protein
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Description
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
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Protein name
Interleukin-21
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Protein short names
IL-21; ZA11; CVID11; DN-452A22.7; IL21
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Uniprot ID
Q9ES17
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Gene Name
Il21
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the soluble form of mouse IL21 (Q9ES17) (Pro 25-Ser 146) was expressed, with an initial Met at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse IL21 consists of 123 amino acids and has a calculated molecular mass of 14.3KDa. It migrates as a 15 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells.
The ED50 for this effect is typically 4-20 ng/ml. -
Validations
Mouse IL21 / Interleukin 21 Protein SDS-PAGE
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