• Human IL21 recombinant protein (Native)

Human IL21 recombinant protein (Native)

Cat.#: 514886

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Product Information

  • Product Name
    Human IL21 recombinant protein (Native)
  • Documents
  • Description
    IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation)Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein name
    Interleukin-21
  • Protein short names
    CVID11,IL-21,Za11
  • Uniprot ID
    Q9HBE4-1
  • Gene Name
    Interleukin-21; IL-21; Za11
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human IL21 isoform 1 (Q9HBE4-1) (Gln23-Ser155) was expressed and purified with an initial Met.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL-21 consists of 134 amino acids and has a calculated molecular mass of 15.6 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells.
    The ED50 for this effect is 0.4-2 ng/mL.
  • Validations

    Human IL21/IL-21 Protein 14105

    Human IL21/IL-21 Protein 14105

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"