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Human IL-21 recombinant protein

Cat.#: 501827

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Product Information

  • Product Name
    Human IL-21 recombinant protein
  • Documents
  • Description
    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
  • Protein name
    Interleukin-21
  • Protein short names
    IL-21; IL21; CVID11; DN-452A22.7; ZA11
  • Uniprot ID
    Q9HBE4
  • Gene Name
    IL21
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human IL-21 isoform 1 (Q9HBE4-1) (Gln 23-Ser 155) was expressed and purified, with an initial Met.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL-21 consisting of 134 amino acids and has a calculated molecular mass of 15.6 kDa. It migrates as an approximately 17 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind human IL-21R in a functional ELISA.
    2. Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.4-2 ng/ml.
  • Validations

    Human Interleukin-21 / IL-21 Protein SDS-PAGE

    Human Interleukin-21 / IL-21 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"