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Product Name
Human IL-1R2/CD121b recombinant protein
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Description
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
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Protein name
Interleukin-1 receptor type 2
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Protein short names
IL1R2C; IL1R-2; IL-1RT-2; CDW121B; IL1RB; IL-1R-2; IL-1 TYPE II RECEPTOR; CD121 ANTIGEN-LIKE FAMILY MEMBER B; INTERLEUKIN-1 RECEPTOR BETA; CD121B; IL-1RT2; RATTUS NORVEGICUS; IL-1R-BETA
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Uniprot ID
P27930
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Gene Name
IL1R2; IL1RB
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IL1R2 (NP_004624.1) (Met 1-Glu 343) was expressed with five amino acids (DDDDK) at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL1R2 consists of 336 amino acids and predicts a molecular mass of 38.4 KDa. It migrates as an approximately 49 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Immobilized human IL1R2 at 10 μg/ml (100 μl/well) can bind biotinylated human IL1B-His (cat:501519), The EC50 of biotinylated human IL1B-His (cat:501519) is 0.14-0.34 μg/ml.
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Validations
Human IL1R2 / IL1RB / CD121b Protein SDS-PAGE
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