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Product Name
Human IL-1RA/IL1RN (Fc Tag) recombinant protein
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Description
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.
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Protein name
Interleukin-1 receptor antagonist protein
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Protein short names
IL-1RA; DIRA; IL-1RN; IL-1RA3; RP23-218B17.2; IRAP; ICIL-1RA; IL1RN; MGC10430; IL1F3; IL1RA; MVCD4; F630041P17RIK
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Uniprot ID
P18510
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Gene Name
IL1RN; IL1F3; IL1RA
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human IL1RA (NP_776214.1) (Arg 26-Glu 177) was fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL1RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 389 amino acids and predicts a molecular mass of 43.8 kDa. As a result of glycosylation, the rh IL1RA/Fc monomer migrates as approximately 45-55 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Validations
Human IL-1RA / IL1RN Protein (Fc Tag) SDS-PAGE
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