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Product Name
Rat IL-1RA/IL1RN (Fc Tag) recombinant protein
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Description
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity).
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Protein name
Interleukin-1 receptor antagonist protein
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Protein short names
IL1F3; MGC10430; ICIL-1RA; IRAP; IL1RN; F630041P17RIK; MVCD4; IL1RA; DIRA; IL-1RN; IL-1RA; IL-1RA3; RP23-218B17.2
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Uniprot ID
P25086
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Gene Name
Il1rn; Il-1ra
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat IL1RN (P25086) (His27-Gln178) was expressed, fused with Fc region of human IgG1 at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat IL1RN comprises 412 amino acids and predicts a molecular mass of 45.8 kDa. The apparent molecular mass of the recombinant protein is approximately 47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Immobilized rat IL1R1-His (Cat:504237) at 10 μg/ml (100 μl/well) can bind rat Fc-IL1RN, The EC50 of rat Fc-IL1RN is 5.1-11.9 ng/ml.
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Validations
Rat IL-1RA / IL1RN Protein (Fc Tag) SDS-PAGE
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