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Product Name
Human IL-28A / IL28A (His Tag) recombinant protein
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Description
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
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Protein name
Interferon lambda-2
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Protein short names
IL-28A; IL28A; EG330496; ZCYTO20
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Uniprot ID
Q8IZJ0
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Gene Name
IFNL2; IL28A; ZCYTO20
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Source/Expression Host
Yeast
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Expression Plasmid/cDNA
A DNA sequence encoding the human IFNL2 (NP_742150.1) (Val26-Val200) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IFNL2 consists 185 amino acids and predicts a molecular mass of 21.1 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Activity
Measured in antiviral assays using HepG2 cells infected with vesicμLar stomatitis virus. The ED50 for this effect is typically 1.7-6.8 ng/mL.
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Validations
Human IL-28A / IL28A Protein (His Tag)
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