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Product Name
Mouse ICOS/AILIM/CD278 (Fc Tag) recombinant protein
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Description
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
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Protein name
Inducible T-cell costimulator
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Protein short names
MGC39850; CVID1; H4; ICOS; AILIM; LY115; CCLP; CRP-1; CD278; CH29-120A16.4
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Uniprot ID
Q9WVS0
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Gene Name
Icos; Ailim
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse ICOS (Q9WVS0) extracellular domain (Met 1-Leu 142) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse ICOS/Fc is a disulfide-linked homodimer. The reduced monomer consists of 363 amino acids and has a predicted molecular mass of 40.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmICOS/Fc monomer is approximately 40-45 kDa.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse ICOS / AILIM / CD278 Protein (Fc Tag) SDS-PAGE
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