Human ICOS/AILIM (Fc tag) recombinant protein

Human ICOS/AILIM (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige

inducible T-cell costimulator(ICOS)

AILIM

Q9Y6W8

Human Cells

A DNA sequence encoding the Human ICOS/AILIM Glu21-Phe141 is expressed with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.