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Product Name
Human TNFSF10/APO2L/TRAIL (His tag) recombinant protein
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Description
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
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Protein name
tumor necrosis factor superfamily member 10(TNFSF10)
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Protein short names
APO2L; TRAIL
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Uniprot ID
P50591
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TNFSF10/APO2L/TRAIL Val114-Gly281 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TNFSF10/APO2L/TRAIL (His tag) recombinant protein
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