Human TNFRSF4/TXGP1L (His tag) recombinant protein

Human TNFRSF4/TXGP1L (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

TNF receptor superfamily member 4(TNFRSF4)

TXGP1L

P43489

Human Cells

A DNA sequence encoding the Human TNFRSF4/TXGP1L Leu29-Ala216 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.