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Product Name
Human SNX17 Recombinant protein (GST tag)
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Description
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). {PubMed:15121882, PubMed:15769472, PubMed:16712798, PubMed:19005208, PubMed:21512128, PubMed:22492727}.
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Protein name
Sorting nexin-17
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Protein short names
KIAA0064
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Uniprot ID
Q15036
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Gene Name
SNX17; KIAA0064
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SNX17 (NP_055563.1) 17-226 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human SNX17 SDS-PAGE
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