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  • Human S100A4  (Fc Tag) recombinant protein

Human S100A4 (Fc Tag) recombinant protein

Cat.#: 503332

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Product Information

  • Product Name
    Human S100A4 (Fc Tag) recombinant protein
  • Documents
  • Description
    S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin ?, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.
  • Protein name
    Protein S100-A4
  • Protein short names
    S100A4; P9KA; 42A; METASTASIN; PK9A; FSP1; PEL98; CAPL; 18A2; MTS1
  • Uniprot ID
    P26447
  • Gene Name
    S100A4; CAPL; MTS1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human S100A4 (NP_002952.1) (Met 1-Lys 101) was expressed with the fused Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human Fc/S100A4 is a disulfide-linked homodimeric protein. The reduced monomer consists of 338 amino acids and has a predicted molecular mass of 38.4 kDa. As a result of glycosylation, the apparent molecular mass of rhFc/S100A4 monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human S100A4 Protein (Fc Tag) SDS-PAGE

    Human S100A4 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"