Mouse S100A4 (Fc Tag) recombinant protein
S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin ?, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.
Protein short names
METASTASIN; PK9A; 42A; P9KA; S100A4; 18A2; MTS1; PEL98; CAPL; FSP1
S100a4; Capl; Mts1
A DNA sequence encoding the mouse S100A4 (P07091) (Ala2-Lys101) was expressed with the Fc region of human IgG1 at the N-terminus.
The recombinant mouse S100A4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 360 amino acids and has a predicted molecular mass of 40 kDa. The apparent molecular mass of the protein is approximately 38-42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
> 95 % as determined by SDS-PAGE
Mouse S100A4 Protein (Fc Tag) SDS-PAGE
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