Human PROX1 Recombinant protein (GST tag)

Human PROX1 Recombinant protein (GST tag)

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Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {PubMed:23723244, PubMed:22733308}.

Prospero homeobox protein 1

Q92786

PROX1

E. coli

A DNA sequence encoding the human PROX1 (XP_054193712.1) 546-736 aa was fused with the N-terminal GST tag

Human

Not tested.