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Product Name
Human PRDX1/PAGA/PAGB/TDPX2 (His tag) recombinant protein
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Description
Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
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Protein name
peroxiredoxin 1(PRDX1)
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Protein short names
PAGA; PAGB; TDPX2
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Uniprot ID
Q06830
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human PRDX1/PAGA/PAGB/TDPX2 Met1-Lys199 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human PRDX1/PAGA/PAGB/TDPX2 (His tag) recombinant protein
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