Cart 2

Human PRDM2/RIZ1 (GST Tag) recombinant protein

Cat.#: 504107

Size:

Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human PRDM2/RIZ1 (GST Tag) recombinant protein
  • Documents
  • Description
    PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is a S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and act as a transcriptional activator. In addition, PRDM2 (RIZ) is able to binds to the retinoblastoma protein (RB) and also Interacts with GATA3.
  • Protein name
    PR domain zinc finger protein 2
  • Protein short names
    KMT8; ZNFPR1C1; RP5-1177E19.1; 4833427P12RIK; MTB-ZF; HUMHOXY1; PRDM2; RIZ1; RP23-185C16.1; GM1033; GM19732; RIZ; RIZ2; E330024L24RIK
  • Uniprot ID
    Q13029
  • Gene Name
    PRDM2; KMT8; RIZ
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal segment of human PRDM2 (NP_036363.2) (Met 1-Ala 200), containing the SET domian, was fused with the GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PRDM2/GST chimera consists of 432 amino acids and predicts a molecular mass of 49.6 kDa as estimated in SDS-PAGE under reducing conditions.
  • Purity
    > 86 % as determined by SDS-PAGE
  • Validations

    Human PRDM2 / RIZ1 Protein (GST Tag) SDS-PAGE

    Human PRDM2 / RIZ1 Protein (GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"