Anti-PRDM2/RIZ1 antibody

Anti-PRDM2/RIZ1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to PRDM2/RIZ1

ELISA, IHC-P

Human PRDM2 / KMT8

4833427P12Rik antibody; E330024L24Rik antibody; Gm1033 antibody; RIZ antibody; KMT8 antibody; RIZ1 antibody; RIZ2 antibody; MTB-ZF antibody; HUMHOXY1 antibody; Riz antibody; KMT8 antibody; Riz1 antibody; Gm1033 antibody; Gm19732 antibody; Znfpr1c1 antibody; 4833427P12Rik antibody; E330024L24Rik antibody; HUMHOXY1 antibody; KMT8 antibody; KMT8 antibody; MTB-ZF antibody; Prdm2 antibody; PRDM2 antibody; RIZ antibody; Riz antibody; RIZ1 antibody; RIZ1 antibody; RIZ2 antibody; RP23-185C16.1 antibody; RP5-1177E19.1 antibody; Znfpr1c1 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human PRDM2 (rh PRDM2; NP_036363.2; Met 1-Ala 200). PRDM2 specific IgG was purified by human PRDM2 affinity chromatography

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is a S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and act as a transcriptional activator. In addition, PRDM2 (RIZ) is able to binds to the retinoblastoma protein (RB) and also Interacts with GATA3.

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