Human PAIP1 Recombinant protein (GST tag)

Human PAIP1 Recombinant protein (GST tag)

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Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {PubMed:11051545, PubMed:9548260}.

Polyadenylate-binding protein-interacting protein 1

Q9H074

PAIP1

E. coli

A DNA sequence encoding the human PAIP1 (NP_006442.2) 259-479 aa was fused with the N-terminal GST tag

Human

Not tested.