Human MMS19 Recombinant protein (His tag)

Human MMS19 Recombinant protein (His tag)

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Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. {PubMed:11071939, PubMed:11328871, PubMed:20797633, PubMed:22678361, PubMed:22678362}.

MMS19 nucleotide excision repair protein homolog

MMS19L

Q96T76

MMS19; MMS19L

E. coli

A DNA sequence encoding the human MMS19 (NP_001338285.1) 723-1069 aa was fused with the polyhistidine tag

Human

Not tested.