Human LILRB2 / ILT4 / LIR-2 (Fc Tag) recombinant protein

Human LILRB2 / ILT4 / LIR-2 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

Leukocyte immunoglobulin-like receptor subfamily B member 2

IG-LIKE TRANSCRIPT 4; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR 2; LILRA6; XXBAC-BCX105G6.12-005; ILT-4; MEMBER 6; LIR-2; MIR10; SUBFAMILY B (WITH TM AND ITIM DOMAINS); SUBFAMILY A (WITH TM DOMAIN); EUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR; CD85 ANTIGEN-LIKE FAMILY MEMBER D; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 2 SOLUBLE ISOFORM; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR; CD85D; MIR-10; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 2; ILT4; IMMUNOGLOBULIN-LIKE TRANSCRIPT 4; LIR2; MONOCYTE/MACROPHAGE IMMUNOGLOBULIN-LIKE RECEPTOR 10; MEMBER 2; LILRB2

Q8N423

LILRB2; ILT4; LIR2; MIR10

Human Cells

A DNA sequence encoding the human LILRB2 (AAH36827.1) (Met1-Val461) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human LILRB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 681 amino acids and has a predicted molecular mass of 74.8 kDa. The apparent molecular mass of the protein is approximately 93 kDa in SDS-PAGE under reducing conditions.

> 85 % as determined by SDS-PAGE

Measured by its ability to support the adhesion of HSB2 human peripheral blood acute lymphoblastic leukemia cells.
When 8 x 10E4 cells/well are added to LILRB2 coated plates (4.4 μg/mL with 100 μL/well), approximately >45% cells will adhere for 1 hour incubation at 37℃.