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Product Name
Human KDM5C Recombinant protein (His tag)
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Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {UniProtKB:P41230, PubMed:17320160, PubMed:17320161, PubMed:17468742}.
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Protein name
Lysine-specific demethylase 5C
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Protein short names
DXS1272E; JARID1C; SMCX; XE169
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Uniprot ID
A0A8I5KQR8
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Gene Name
KDM5C; DXS1272E; JARID1C; SMCX; XE169
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human KDM5C (NP_001269551.1) 1-351 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human KDM5C SDS-PAGE
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