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  • Human IL31 recombinant protein

Human IL31 recombinant protein

Cat.#: 518727

Special Price 156.8 USD

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Product Information

  • Product Name
    Human IL31 recombinant protein
  • Documents
  • Description
    Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rβ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
  • Protein name
    interleukin 31(IL31)
  • Uniprot ID
    Q6EBC2
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human IL31 Ser24-Thr164 is expressed.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human IL31 recombinant protein

    Human IL31 recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"