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Product Name
Recombinant Human IL-31 protein (His tag)
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Description
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR; May function in skin immunity;
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Protein short names
IL31
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Uniprot ID
Q6EBC2
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Gene Name
interleukin 31
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Source/Expression Host
HEK293
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Expression Plasmid/cDNA
A DNA sequence encoding the human IL31 (NP_001014358.1) (Met1-Thr164) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL31 consists of 152 amino acids and predicts a molecular mass of 17.3 KDa. It migrates as an approximately 31.8 KDa band in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to induce STAT3 activation in U‑87 cells. The ED50 for this effect is 11-45 ng/mL.
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Validations
Recombinant Human IL-31 protein (His tag)
Related Products / Services
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