Human IL23A recombinant protein (C-human IgG1-Fc)
IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised a unique p19 subunit and p40 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway [11,12]. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Interleukin-23 subunit alpha
Protein short names
Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19
A DNA sequence encoding the human IL23A (NP_057668.1) (Met1-Pro189) was expressed with the Fc region of human IgG1 at the C-terminus.
The recombinant human IL23A consists of 408 amino acids and predicts a molecular mass of 45.4 kDa.
> 85 % as determined by SDS-PAGE.
Human IL-23A Protein 14951
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