Human IL-35 (Fc tag) recombinant protein

Human IL-35 (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-35 is a newest and potent suppressive cytokine of the IL-12 family. Unlike other members of the IL-12 family which are produced mainly by antigen-presenting cells (APCs), IL-35 has been identified as a potentially immunosuppressive cytokine primarily produced by regulatory T (Treg) cells, and to a lesser extent by activated dendritic cells and macrophages. IL-35 is composed of the IL-12 p35 subunit and the IL-27 Epstein–Barr virus-induced protein 3 (EBI3) subunit. IL-35 plays an important role in many disease models and has been recently shown to have additional functions aside from inhibition of proliferation, including inducing its own expression in non-Treg cells.

Interleukin-35

Q14213&P29459

Human Cells

A DNA sequence encoding the Human IL-35 Arg21-Lys229&Arg23-Ser219 is expressed with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.