Human IGF1 recombinant protein (Native)

Human IGF1 recombinant protein (Native)

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IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

Insulin-like growth factor I

IGF-1,IGF-I,IGF1A,IGFI,IGF‑I,MGF

P05019

Insulin-like growth factor I; IGF-I; Mechano growth factor; MGF; Somatomedin-C

Yeast

A DNA sequence encoding the human IGF1 (P05019, E51R) (Gly49-Ala118) was expressed with a 13 amino acids (MFPAMPLSSLFVN)at its N-terminus.

Human

The recombinant human IGF1 consists of 83 amino acids and predicts a molecular mass of 9.1 kDa.

> 95% as determined by SDS-PAGE.

Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is typically 1.5-6 ng/mL.