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Product Name
Human FAS/APT1/FAS1/TNFRSF6 (His tag) recombinant protein
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Description
FAS is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
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Protein name
Fas cell surface death receptor(FAS)
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Protein short names
APT1; FAS1; TNFRSF6
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Uniprot ID
P25445
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human FAS/APT1/FAS1/TNFRSF6 Gln26-Asn173 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human FAS/APT1/FAS1/TNFRSF6 (His tag) recombinant protein
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