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Product Name
Anti-CD95/APO-1/TNFRSF6 antibody
- Documents
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Description
Rabbit monoclonal to CD95/APO-1/TNFRSF6
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Tested applications
FCM
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Species reactivity
Rat CD95 / APO-1 / TNFRSF6 / FAS
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Alternative names
ALPS1A antibody; APO-1 antibody; APT1 antibody; CD95 antibody; FAS antibody; FAS1 antibody; FASTM antibody; TNFRSF6 antibody; lpr antibody; APO1 antibody; APT1 antibody; CD95 antibody; TNFR6 antibody; Tnfrsf6 antibody; AI196731 antibody; APT1 antibody; CD95 antibody; FAS1 antibody; APO-1 antibody; FASTM antibody; ALPS1A antibody; TNFRSF6 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD95 / APO-1 / TNFRSF6 / FAS (rR CD95 / APO-1 / TNFRSF6 / FAS; NP_631933.2; Met1-Lys170).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
FCM: 0.5-2 μg/Test
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Validations
CD95 / APO-1 / TNFRSF6 / FAS Antibody, Rabbit MAb, Flow Cytometry
Flow cytometric analysis of Rat FAS(CD95) expression on SD rat splenocytes. Cells were stained with purified anti-Rat FAS(CD95), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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Background
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"