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Product Name
Anti-Fas Rabbit antibody
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Description
Fas Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC
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Species reactivity
Human
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Alternative names
APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Fas
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
IHC: 1/50
ICC/IF: 1/50
FC: 1/20
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Validations
Western blot detection of Fas in Hela,Jurkat cell lysates using Fas Rabbit mAb(1:500 diluted).Predicted band size:38kDa.Observed band size:45kDa.
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Background
Swiss-Prot Acc.P25445.Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"