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Product Name
Human Cystatin 7 / CST7 recombinant protein
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Description
The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.
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Protein name
Cystatin-F
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Protein short names
CST7; MGC151424; CMAP; CYSTATIN F; RP23-156P22.1; MGC151426
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Uniprot ID
O76096
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Gene Name
CST7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
The mature form of the human Cystatin F (NP_003641.3) (Met 1-His 145) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human Cystatin F consists of 132 amino acids and predicts a molecular mass of 15.2 kDa. As a result of glycosylation, the apparent molecular mass of rhCystatin F is approximately 25 kDa in SDS-PAGE.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human Cystatin 7 / CST7 Protein SDS-PAGE
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