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Product Name
Human Cystatin 7 / CST7 (Fc Tag) recombinant protein
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Description
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
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Protein name
Cystatin-F
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Protein short names
MGC151426; RP23-156P22.1; CMAP; CYSTATIN F; CST7; MGC151424
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Uniprot ID
O76096
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Gene Name
CST7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human Cystatin F precursor (NP_003641.3) (Met 1-His 145) was expressed with the fused Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human Cystatin-F/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 364 amino acids and predicts a molecular mass of 41.3 kDa. As a result of glycosylation, the rh Cystatin-F/Fc monomer migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit active Cathepsin L. Cleavage of a fluorogenic peptide substrate Z-LR-AMC (R&D Systems, Catalog#ES008). The IC50 value is <5 nM.
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Validations
Human Cystatin 7 / CST7 Protein (Fc Tag) SDS-PAGE
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