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Product Name
Human CDKN1A/CAP20/CDKN1/CIP1 (His tag) recombinant protein
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Description
Cyclin-Dependent Kinase Inhibitor 1 (CDKN1A) is a member of the CDI family. CDKN1A is widely expressed in all adult tissues, but low expressed in the brain tissue. CDKN1A can be induced by p53/TP53, mezerein and IFNB1, repressed by HDAC1. CDKN1A may be an important intermediate, by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage, CDKN1A can bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
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Protein name
cyclin dependent kinase inhibitor 1A(CDKN1A)
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Protein short names
CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1
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Uniprot ID
P38936
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human CDKN1A/CAP20/CDKN1/CIP1 Ser2-Pro164 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human CDKN1A/CAP20/CDKN1/CIP1 (His tag) recombinant protein
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